Globin Composition and Synthesis of Hemoglobins in Developing Fetal Mice Erythroid Cells

Science  15 Sep 1967:
Vol. 157, Issue 3794, pp. 1327-1329
DOI: 10.1126/science.157.3794.1327


Fetal mouse erythropoiesis proceeds initially in yolk-sac blood islands (8 to 12 days) and, subsequently, in liver (12 to at least 16 days). Yolksac cells synthesize three hemoglobins, Hb EI, Hb EII and Hb EIII. Hb EI has x- and y-globin chains; Hb EII has α and y; HB EIII, α and z. No detectable β-globin is formed in these cells. Liver erythroid cells form only adult hemoglobin, composed of α- and β-chains.