DDT: Interaction with Nerve Membrane Conductance Changes

Science  22 Sep 1967:
Vol. 157, Issue 3795, pp. 1438-1440
DOI: 10.1126/science.157.3795.1438


The falling phase of action potentials of lobster giant axons is prolonged by DDT; finally a plateau phase is produced like cardiac action potentials. In axons poisoned with DDT, peak transient (sodium) currents associated with step depolarizations are turned off very slowly, and steady-state (potassium) currents are markedly suppressed. These two changes would cause the prolongation of action potentials and are considered the major ionic mechanisms of DDT action.