Serotonin Release from Brain Slices by Electrical Stimulation: Regional Differences and Effect of LSD

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Science  22 Sep 1967:
Vol. 157, Issue 3795, pp. 1461-1463
DOI: 10.1126/science.157.3795.1461


Slices of rat brain which had accumulated tritiated serotonin either in vivo or in vitro were superfused and electrically stimulated. There occurred a marked release of the exogenous amine and, to a lesser extent, its deaminated metabolites, which varied with the region of brain tested and was inhibited by lysergic acid diethylamide.