Erythrocyte Abnormality in Human Myopathy

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Science  29 Sep 1967:
Vol. 157, Issue 3796, pp. 1577-1578
DOI: 10.1126/science.157.3796.1577


Erythrocyte ghosts isolated from myopathic patients responded to 10-4 molar ouabain with a dramatic increase in adenosine triphosphatase activity, while identical preparations from normal donors were inhibited by the same drug. These results have been interpreted in terms of a disease-related change in membrane integrity bearing upon function of the transport enzyme.