Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation

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Science  13 Oct 1967:
Vol. 158, Issue 3798, pp. 272-274
DOI: 10.1126/science.158.3798.272


Carotid-to-jugular cross circulation between partially hepatectomized and normal rats, via polyethylene cannulas, stimulated incorporation of 14C-thymidine into hepatic DNA in the normal partners when it was maintained for 19 hours at a flow rate of about 2 milliliters per minute. Cross circulation for 7 hours or less was ineffective.