5-Oxo-5H-benzo[e]isochromeno-[4,3-b] indole, a New Type of Highly Sarcomagenic Lactone

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Science  20 Oct 1967:
Vol. 158, Issue 3799, pp. 387-388
DOI: 10.1126/science.158.3799.387


The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.