Slow Virus Kidney Disease of Mice

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Science  27 Oct 1967:
Vol. 158, Issue 3800, pp. 502-504
DOI: 10.1126/science.158.3800.502


Preliminary observations based on organ weight differential, renal function, and glomerular lesions in mice infected neonatally with lymphocytic choriomeningitis indicate the presence of a slow virus-induced kidney disease of mice. This condition is accompanied by a marked decrease in the size of the kidneys, with progressive diminution of renal function, as shown by measurements of creatinine and urea clearance.