Hydraulic Compression of Mice to 166 Atmospheres

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Science  10 Nov 1967:
Vol. 158, Issue 3802, pp. 793-794
DOI: 10.1126/science.158.3802.793


Hydraulic uniform compression elicited tremors, uncoordinated limb movements, and tonic convulsions in liquid-breathing mice at pressures ranging from 50 to 100 atmospheres. Such abnormal muscular activity was observed neither in control animals nor in mice caudally to a spinal transection. Uniform compression of isolated preparations of mouse muscle in saline failed to contract at pressures up to 200 atmospheres.