Polymerization of Hemoglobins of Mouse and Man: Structural Basis

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Science  10 Nov 1967:
Vol. 158, Issue 3802, pp. 800-802
DOI: 10.1126/science.158.3802.800-a


Human hemoglobin Pôrto Alegre and mouse hemoglobin (BALB/cJ) polymerize by forming intermolecular disulfide bridges. Both hemoglobins have externally oriented, reactive cysteinyl residues in the A-helix of the beta chain. Hemoglobin Pôrto Alegre can be designated as α2 β29 Ser → Cys. The crysteinyl residue of the mouse hemoglobin is at position 13 in the beta chain.