Cholinergic Binding Capacity of Proteolipids from Isolated Nerve-Ending Membranes

Science  17 Nov 1967:
Vol. 158, Issue 3803, pp. 928-929
DOI: 10.1126/science.158.3803.928


The capacity for binding dimethyl d-tubocurarine-C14 was studied in isolated nerve-ending membranes from cerebral cortex and myelin. After treatment of the membrane with organic solvents most of the radioactivity was recovered in the extract. Preliminary evidence indicates that dimethyl d-tubocurarine-C14 is not bound to lipids or glycolipids. While the proteolipids of myelin have a low binding capacity, the results obtained with the nerve-ending membranes rich in acetylcholinesterase suggest that the cholinergic receptor may be a special type of proteolipid.