Enzyme Concentrations in Tissues

Science  17 Nov 1967:
Vol. 158, Issue 3803, pp. 936-937
DOI: 10.1126/science.158.3803.936

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Apparent enzyme concentrations in cells and in mitochondria are calculated from data available in the literature. These values are 10-6 to 10-5 moles per kilogram of tissue. It is pointed out that these concentrations are much higher than those used in enzymatic studies in vitro. Metabolic interpretations of experiments in vitro should consider this additional departure from conditions in vivo.