Audiogenic Seizure Susceptibility Induced in C57B1/6J Mice by Prior Auditory Exposure

See allHide authors and affiliations

Science  17 Nov 1967:
Vol. 158, Issue 3803, pp. 938-940
DOI: 10.1126/science.158.3803.938-a


Pronounced susceptibility to audiogenic seizures was produced in highly resistant C57B1/6J mice after earlier exposure to a loud electric bell. There is a critical period between initial acoustic presentation and subsequent testing for susceptibility; this suggests a minimum age and a minimum lapse of time during which this "priming" is effective.