Antihemophilic Factor Release by Perfused Liver and Spleen: Relationship to Hemophilia

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Science  24 Nov 1967:
Vol. 158, Issue 3804, pp. 1060-1061
DOI: 10.1126/science.158.3804.1060


As judged by perfusion of isolated organs an antihemophilic factor is produced in the liver and the spleen. Perfusates (from hemophiliacs) that are deficient in the human anti-hemophilic factor stimulate production of the factor during perfusion. Apparently there is an antihemophilic-factor-stimulating substance in the plasma of hemophiliacs. The data suggest that splenic homotransplantation might alleviate the symptoms of hemophilia.