Lymphocytic Choriomeningitis: Production of Antibody by "Tolerant" Infected Mice

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Science  01 Dec 1967:
Vol. 158, Issue 3805, pp. 1193-1195
DOI: 10.1126/science.158.3805.1193


Newborn mice infected with lymphocytic choriomeningitis virus are not immunologically tolerant to the agent but, rather, appear to make antibody to the virus. This antibody was detectable only in the kidneys, where presumably it had been deposited in the glomeruli in the form of complexes of antibody, virus, and complement.