Myxovirus-Like Structures in a Case of Human Chronic Polymyositis

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Science  15 Dec 1967:
Vol. 158, Issue 3807, pp. 1453-1455
DOI: 10.1126/science.158.3807.1453


Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1½ years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.