Synovial Cell Synthesis of a Substance Immunologically Like Cartilage Proteinpolysaccharide

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Science  15 Dec 1967:
Vol. 158, Issue 3807, pp. 1464-1467
DOI: 10.1126/science.158.3807.1464


Fluids from joints contain a substance that reacts immunologically like one of two known antigenic components of articular cartilage proteinpolysaccharide. This newly recognized substance occurs in the lining cells of synovial membranes as shown by indirect immunofluorescence. The localization of this substance in tissue culture cells derived from synovial membranes and its identification in the culture medium supports the suggestion that it is synthesized by lining cells. Rheumatoid synovial cells contain less of this substance.