Pemoline Levels in Brain: Enhancement by Dimethyl Sulfoxide

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Science  15 Dec 1967:
Vol. 158, Issue 3807, pp. 1479-1480
DOI: 10.1126/science.158.3807.1479


Pemoline-C14 dissolved in dimethyl sulfoxide and injected intraperitoneally into rats was found in larger amounts in the brain than was a similar dose given in 0.3 percent tragacanth suspension. This appeared to be related to a partial breakdown of the blood-brain barrier in vivo by the dimethyl sulfoxide.