Efficiency of the First Component of Complement (C'1) in the Hemolytic Reaction

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Science  22 Dec 1967:
Vol. 158, Issue 3808, pp. 1590-1592
DOI: 10.1126/science.158.3808.1590


With the use of the first component of guinea pig complement (C'1) labeled in vivo with 14C-amino acids, we have obtained evidence that, under the conditions required for the assay of C'1, each molecule of C'1 capable of interaction with cell surface antigen-antibody complexes is capable of initiating the reaction sequence that leads to lysis of the cell.