Actinomycin D Blocks Formation of Memory of Shock-Avoidance in Goldfish

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Science  22 Dec 1967:
Vol. 158, Issue 3808, pp. 1600-1601
DOI: 10.1126/science.158.3808.1600


When 2 micrograms of antinomycin D was injected intracranially into goldfish immediately after a training session, the formation of long-term memory of a shock-avoidance was blocked. The results are discussed in relation to similar findings with acetoxycycloheximide and puromycin in the goldfish and with apparently conflicting results in the mouse.