Salicylanilides: A New Group of Active Uncouplers of Oxidative Phosphorylation

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Science  29 Dec 1967:
Vol. 158, Issue 3809, pp. 1694-1695
DOI: 10.1126/science.158.3809.1694


Investigations using housefly mitochondria revealed several salicylanilide derivatives as the most effective uncoupling agents of oxidative phosphorylation reported so far. Even greater inhibition of the associated Pi-adenosine triphosphate exchange was shown with these compounds in both housefly and rat-liver mitochondria, and close similarity was observed between the two types of organelles.