Action Potentials without Contraction in Frog Skeletal Muscle Fibers with Disrupted Transverse Tubules

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Science  29 Dec 1967:
Vol. 158, Issue 3809, pp. 1702-1703
DOI: 10.1126/science.158.3809.1702


Action potentials, with no accompanying contraction, were recorded from muscle fibers in which the transverse tubular system had been disrupted. The results show that action potentials require an intact transverse tubular system to cause contraction. Furthermore, both the after-depolarization following a single action potential and the slower, late afterpotential following a train of action potentials were absent in this preparation. Therefore, both phenomena must normally involve the transverse tubular system.