Selective Phagocytosis: A New Concept in Protein Catabolism

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Science  05 Jan 1968:
Vol. 159, Issue 3810, pp. 107-110
DOI: 10.1126/science.159.3810.107


The clearance of different metabolic products derived from two plasma proteins, prothrombin and fibrinogen, was studied with the aid of the isolated, perfused rat liver. Active thrombin and fibrin were rapidly cleared by the Kupffer cells. Inactive thrombin and a partially degraded fibrin molecule were also cleared but at much slower rates. This difference in clearance rates suggests the presence of a high degree of selectivity in the clearance of altered plasma proteins.