Collagen Synthesis by Cells Synchronously Replicating DNA

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Science  05 Jan 1968:
Vol. 159, Issue 3810, pp. 91-93
DOI: 10.1126/science.159.3810.91


Replication and the performance of a differentiated function have been considered antagonistic processes. When cells in culture are partially tially synchronized with 5-fluoro-2'-deoxyuridine (FUdR), the synthesis of the specialized protein (collagen) is not reduced during chromosomal replication (S period). Collagen synthesis varies with general protein synthesis through the S period.