Viral Neoplastic Transformation of Hamster Prostate Tissue in vitro

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Science  12 Jan 1968:
Vol. 159, Issue 3811, pp. 200-201
DOI: 10.1126/science.159.3811.200


Cultures of hamster prostatic tissues infected with simian virus 40 undergo transformation in vitro, and the transformed cells produce malignant tumors when injected into homologous hosts. Tartrate-inhibited acid phosphastase is found in the cultures of transformed cells and in the tumors they produce. Tartrate-inhibited acid phosphatase activity is elevated in the serum of tumor-bearing animals.