Macrophage Cultures: An Extracellular Esterase

See allHide authors and affiliations

Science  12 Jan 1968:
Vol. 159, Issue 3811, pp. 217
DOI: 10.1126/science.159.3811.217


An enzyme having esterase activity accumulates in the culture media of mouse peritoneal mononuclear leukocytes during differentiation of the cells into macrophages. It has a pH optimum of 6.5 and shows aryl esterase characteristics. The esterase differs from another macrophage hydrolase, acid phosphatase, in its mainly extracellular distribution.