Titration Patterns of a Murine Sarcoma-Leukemia Virus Complex: Evidence for Existence of Competent Sarcoma Virions

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Science  19 Jan 1968:
Vol. 159, Issue 3812, pp. 325-329
DOI: 10.1126/science.159.3812.325


Stocks of inurine sarcoma virus show titration patterns ranging from one-to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that does not need coinfectinig murine leukemia virus to be manifested as a focus-forming unit. The behavior of such nondefective particles is compatible with a postulated leukemia-sarcoma virus hybrid.