Intracerebral Saline: Effect on Memory of Trained Mice Treated with Puromycin

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Science  19 Jan 1968:
Vol. 159, Issue 3812, pp. 330-331
DOI: 10.1126/science.159.3812.330


It was shown that puromycin administered to mice 1 or more days after maze-learning blocks expression of memory; the blockage can be removed by intracerebral injections of saline. We present evidence that intracerebral injections of saline are relatively ineffective in restoring memory when puromycin is administered either before or immediately after training; in these two situations puromycin appears to interfere with consolidation of memory.