Carbon-14 Milk Constituents from Cows Fed Carbamate Labeled with Carbon-14 on the Carbonyl

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Science  16 Feb 1968:
Vol. 159, Issue 3816, pp. 732-733
DOI: 10.1126/science.159.3816.732


Oral administration to a dairy cow of Furadan insecticide (2,2-dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate) labeled with carbon-14 on the carbonyl produced in the milk certain radioactive materials which were not Furadan metabolites. The data suggest that these products were natural milk constituents containing only the carbon-14 atom from the Furadan molecule. Carbon-14-labeled carbon dioxide formed by the hydrolysis of the carbamate insecticide is the apparent precursor of these radiolabeled constituents of the milk.