17β-Estradiol: Inducer of Uterine Hexokinase

See allHide authors and affiliations

Science  01 Mar 1968:
Vol. 159, Issue 3818, pp. 990-991
DOI: 10.1126/science.159.3818.990


Administration of estradiol to ovariectomized rats induced new synthesis of uterine hexokinase which was prevented by actinomycin D, 5-fluorouracil, cycloheximide, or ethionine. The estradiol-induced increase in uterine hexokinase activity was detectable as early as 4 hours. The increase in enzyme activity was dependent upon the dose of the hormone. The evidence indicates that the increased hexokinase activity induced by 17β-estradiol may entail an acceleration of the synthesis of certain RNA species.