Pathogenesis of a Local Graft versus Host Reaction: Immunogenicity of Circulating Host Leukocytes

Science  15 Mar 1968:
Vol. 159, Issue 3820, pp. 1250-1251
DOI: 10.1126/science.159.3820.1250


A local invasive-destructive reaction typical of that seen in allograft rejection occurs when Lewis rat spleen cells are inoculated under the capsule of Lewis kidney freshly grafted into F1 hybrid hosts. Thus the donor lymphoid cells can be immunogenically stimulated by circulating host leukocytes and the interaction of these two cell populations results in nonspecific damage to kidney parenchyma. The results indicate that passenger leukocytes in organ allografts may be important immunogenic agents.