Tetraethylammonium Chloride as an Antidote for Certain Insecticides in Mice

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Science  22 Mar 1968:
Vol. 159, Issue 3821, pp. 1367-1368
DOI: 10.1126/science.159.3821.1367


In tests on mice, tetraethylammonium chloride (TEAC) was superior to atropine sulfate as an antidote for some carbamate insecticides and nicotine; it did not produce the traumatic and sometimes fatal reactions caused by atropine sulfate, although injections of the two antidotes provided equal protection against lethal oral doses of the carbamates Zectran, NIA-10242, and Lannate. The effects of TEAC were not evaluated against the carbamates Sevin and Baygon because acute oral toxicity values could not be determined. Results with Matacil were inconclusive. Tetraethylammonium chloride was not an effective antidote against the organophosphate Parathion, but its use fully eliminates the effects of nicotine intoxication.