Creatine Kinase and Aldolase in Serum: Abnormality Common to Acute Psychoses

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Science  22 Mar 1968:
Vol. 159, Issue 3821, pp. 1368-1370
DOI: 10.1126/science.159.3821.1368


Activity of creatine kinase and aldolase in serum increased in 14 of 16 patients with recent onset of a psychotic reaction, and in five of six patients treated with psychotomimetic drugs. There was either no increase of these enzymes or a slight increase in severely agitated (or depressed) non-psychotic hospitalized patients and chronic psychotic patients. The increase of the enzymes preceded the onset of the acute psychotic symptoms in at least three cases, was highest during the first 2 weeks of a psychotic episode, and sometimes recurred throughout the illness, particularly at times of stress. The creatine kinase in the serum is primarily of the muscle type.