Electron Microscopy of Unstained Biological Material: The Polytropic Montage

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Science  29 Mar 1968:
Vol. 159, Issue 3822, pp. 1464-1467
DOI: 10.1126/science.159.3822.1464


With use of an electronic picture-scanning device and a digital computer, electron micrographs taken of a specimen along several different directions can be superimposed to form a montage that is more informative than the component images. Preliminary results indicate that one may thus study unstained, unshadowed biological material at high resolution.