Human Granulocyte Collagenase

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Science  29 Mar 1968:
Vol. 159, Issue 3822, pp. 1483-1485
DOI: 10.1126/science.159.3822.1483


A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.