Chlorpromazine: Direct Measurement of Differential Behavioral Effect

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Science  29 Mar 1968:
Vol. 159, Issue 3822, pp. 1487-1489
DOI: 10.1126/science.159.3822.1487


A retarded child with a high stereotyped rocking rate was conditioned to pull a ball on a reinforcement schedule in which the fixed ratio aof rewarded to nonrewarded responses was 100. Results show no rocking movements during ball-pulling; but when ball-pulling was on extinction, rocking returned to its original rate. Chlorpromazine blocked rocking movements during extinction, but had no effect on ball-pulling. Delivery of one free reinforcer was sufficient to reinstate ball-pulling after extinction, but the stimulus properties of the free reinforcer were not affected by the drug.