Cytotoxic Action of Stimulated Lymphocytes on Allogenic and Autologous Erythrocytes

Science  19 Apr 1968:
Vol. 160, Issue 3825, pp. 306-309
DOI: 10.1126/science.160.3825.306


Fowl erythrocytes are lysed when exposed to an excess of fowl blood lymphocytes in the presence of phytohemagglutinin. No significant cell damage is seen in the absence of phytohemagglutinin, or when the lymphocytes are replaced by malignant lymphoid cells, thymus cells, or nonlymphoid cells. The lymphocytes remain viable during the reaction. Differences in histocompatibility between lymphocytes and erythrocytes are not required. Autologous lymphocytes are cytotoxic to the same extent as allogenic lymphocytes over a wide range of experimental conditions.