Nerves in Cortical Bone

Science  19 Apr 1968:
Vol. 160, Issue 3825, pp. 327-328
DOI: 10.1126/science.160.3825.327


Modified electron-microscopic techniques permit the sectioning of fully mineralized compact bone. Cortical canals in human femur are extensively innervated. Most nerves are unmyelinated and range from 0.5 to 10 micrometers in diameter. I have found a few mixed nerves (myelinated and unmyelinated fibers), one of which was 130 micrometers in diameter.