Reports

Virus-Induced Hemolysis in Erythrocytes Deficient in Glucose-6-phosphate Dehydrogenase

Science  03 May 1968:
Vol. 160, Issue 3827, pp. 535-537
DOI: 10.1126/science.160.3827.535

Abstract

Red cells from individuals deficient in glucose-6-phosphate dehydrogenase undergo increased autohemolysis when incubated in the presence of influenza-A virus. Normal red cells, but not those from individuals deficient in glucose-6-phosphate dehydrogenase, show increased activity of the hexose monophosphate shunt in the presence of the virus. This increase in shunt activity appears to be related to oxidation of cellular sulfhydryl groups.

Related Content