Reports

Cross-link in Fibrin Polymerized by Factor XIII: ε-(γ-Glutamyl)lysine

Science  24 May 1968:
Vol. 160, Issue 3830, pp. 892-893
DOI: 10.1126/science.160.3830.892

Abstract

ε-(γ-Glutamyl)lysine has been isolated from enzymatic hydrolyzates of cross-linked human fibrin. This compound was not detected in "non-cross-linked" fibrin prepared with ethylenediaminetetraacetic acid, which inhibits factor XIII; intermediate amounts were observed when the fibrin was prepared with glycine ethyl ester, which inhibits factor XIII competitively. These and ancillary experiments furnish conclusive evidence that ε-(γ-glutamyl)lysine cross-links form in human fibrin during polymerization catalyzed by factor XIII.

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