Caudate Unit Responses to Nigral Stimuli: Evidence for a Possible Nigro-Neostriatal Pathway

Science  24 May 1968:
Vol. 160, Issue 3830, pp. 899-900
DOI: 10.1126/science.160.3830.899


Electrical stimulation of the Substantia nigra evokes depressant and facilitatory responses from individually recorded caudate nucleus neurons. These effects resemble those elicited from caudate cells by microiontophoretic ejections of dopamine. Since histochemical evidence suggests that dopamine-containing fibers link the substantia nigra with the caudate, this pathway may mediate the changes in caudate spike rates produced by nigral stimuli.