Mixed Lymphocyte Reaction: An in vitro Test for Antilymphocytic Serum Activity

Science  31 May 1968:
Vol. 160, Issue 3831, pp. 1014-1017
DOI: 10.1126/science.160.3831.1014


When Lewis rats were exposed to antilymphocytic serum, produced in rabbits, to Lewis lymphoid cells, the transformation of their thoracic duct lymphocytes in response to foreign lymphoid cells was markedly reduced in comparison with that in response to similar cells from donors treated with saline or normal rabbit serum. It is suggested that the mixed lymphocyte reaction may be used as an in vitro test for the in vivo activity of antilymphocytic serum.