Aspirin: Action on Receptor in the Tooth

Science  12 Jul 1968:
Vol. 161, Issue 3837, pp. 180-181
DOI: 10.1126/science.161.3837.180


Impulse frequency recorded from dentinal receptors in the cat's tooth provided an indication of sensory excitation. Topical application of aspirin to the dentin promptly inhibited both steady-state discharge and response to a brief heat stimulus. When the drug was washed out, the initial excitability was restored in 15 minutes.