Reports

Metachromatic Leukodystrophy: Diagnosis with Samples of Venous Blood

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Science  09 Aug 1968:
Vol. 161, Issue 3841, pp. 594-595
DOI: 10.1126/science.161.3841.594

Abstract

Arylsulfatase A and B have been demonstrated in preparations of human leukocytes. The level of activity of arylsulfatase A is markedly decreased in the preparations from patients with metachromatic leukodystrophy. Acid phosphatase and arylsulfatase B activities were normal. The assay of arylsulfatase A in leukocyte preparations can be useful in the diagnosis of metachromatic leukodystrophy while obviating the difficulties of current methods.