Interferon: Protection of Cells Infected with an Intracellular Protozoan (Toxoplasma gondii)

Science  23 Aug 1968:
Vol. 161, Issue 3843, pp. 804-806
DOI: 10.1126/science.161.3843.804


Chick and mouse cell monolayers treated with interferon were significantly protected from destruction by toxoplasma. The results suggest that fewer numbers of organisms were released from interferon-treated cells. Interferons were uniformly more active in a viral assay than in a toxoplasma assay, and they had the same properties in both assays. The data suggest that interferon activity may be directed against organisms phylogenetically higher than viruses.