Reports

Annulment of Sterol-Induced Sexual Reproduction by Estradiol in Pythium periplocum

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Science  20 Sep 1968:
Vol. 161, Issue 3847, pp. 1252
DOI: 10.1126/science.161.3847.1252

Abstract

Estradiol prevented cholesterol-induced sexual reproduction by the fungus Pythium periplocum. Inhibition by estradiol was partial at 10-6M and complete at 10-5M, the same concentrations at which cholesterol and β-sitosterol were initially and maximally active. Higher concentrations of estradiol were required for growth inhibition than for inhibition of reproduction.