Inhibitor of Bacterial Growth Released by Human Cells in Culture

Science  27 Sep 1968:
Vol. 161, Issue 3848, pp. 1344-1345
DOI: 10.1126/science.161.3848.1344


Used medium from cultured human cells contains a factor that inhibits growth of the "less virulent" strains of pathogenic bacteria, but only retards growth of the "more virulent" strains. The factor is heat-stable, dialyzable, and unaffected by change in pH; it chromatographs as material of molecular weight between 700 and 1500. There is evidence that this factor is an α-ketoaldehyde attached to a carrier.