Transport of 1-Aminocyclopentanecarboxylic Acid from Feline Cerebrospinal Fluid

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Science  27 Sep 1968:
Vol. 161, Issue 3848, pp. 1363
DOI: 10.1126/science.161.3848.1363


1-Aminocyclopentanecarboxylic acid was cleared from cerebrospinal fluid of the cat by a saturable mechanism. Clearance was inhibited by naturally occurring neutral amino acids. Carrier transport may explain the low ratio of amino acid in spinal fluid to that in plasma.