Reports

Human Prothrombin Activation: Immunochemical Study

See allHide authors and affiliations

Science  04 Oct 1968:
Vol. 162, Issue 3849, pp. 127-128
DOI: 10.1126/science.162.3849.127

Abstract

Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.