Reports

Brain Alcohol Dehydrogenase

Science  04 Oct 1968:
Vol. 162, Issue 3849, pp. 131-132
DOI: 10.1126/science.162.3849.131

Abstract

Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.

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