Brain Serotonin Concentration: Elevation Following Intraperitoneal Administration of Melatonin

Science  11 Oct 1968:
Vol. 162, Issue 3850, pp. 277-278
DOI: 10.1126/science.162.3850.277


The intraperitoneal administration of melatonin to rats caused an increase in brain serotonin concentration, especially in the midbrain. This effect could be demonstrated within 20 minutes of melatonin administration and was not associated with changes in norepinephrine concentration.